Uncovering the First Step in Amyloid Formation for Huntington's Disease

Researchers at the Stowers Institute for Medical Research have identified the structure of the nucleus, the first step in amyloid formation associated with neurodegenerative diseases like Huntington’s. The study suggests a radical method to treat these diseases—halting the initial amyloid formation step. They discovered the nucleus forms within a single protein molecule and inhibiting this formation can potentially stop the disease progression. This approach could change treatment methods for dozens of amyloid-related diseases.