NSMF Blockade Points to New Route in Colorectal Cancer Therapy

South Korean researchers report that silencing NSMF, a regulator of replication stress in colorectal cancer, triggers irreversible aging in cancer cells and slows or halts tumor growth in mouse models, suggesting a potential new therapy that spares healthy tissue. Published in Nucleic Acids Research, the study highlights NSMF as a key driver of cancer cell replication under stress. With rising colorectal cancer rates in younger Americans and calls to lower screening ages, the findings underscore the push for targeted treatments and earlier detection.