"Integrating Multi-Omic Data to Predict Pancreatic Adenocarcinoma Outcomes"

A new multi-omic analytic platform called Molecular Twin Pilot (MT-Pilot) integrates advanced molecular profiling to predict disease survival (DS) in patients with resectable pancreatic ductal adenocarcinoma (PDAC). The platform incorporates data from tumor and host samples, including computational pathology features, and utilizes machine learning models to develop predictive biomarker panels. The study reveals that plasma proteins are critical biomarkers for predicting survival, outperforming the commonly used CA 19-9 biomarker. The multi-omic models provide insights into potential pathways and therapeutic targets for PDAC, demonstrating the platform's potential to impact clinical care and scientific discovery across various cancers.