Unveiling the Link Between Aging and Epigenetic Clocks

This article explores the concept of adaptation in aging, focusing on cellular senescence, epigenetic clocks, and stem cell alterations. It discusses the role of programmed cell death, DNA damage response, and wound healing in the aging process. The authors highlight the importance of senescent cells and their clearance, as well as the interplay between senescent cells and immune surveillance. The article also discusses the impact of oxidative stress, collagen fragmentation, and changes in extracellular matrix components on aging. Overall, the article provides insights into the mechanisms underlying adaptation and cellular changes during aging.