Radiation-exposed fathers linked to subtle DNA changes in their children
A Scientific Reports study analyzing whole-genome data from 130 offspring of Chernobyl cleanup workers, 110 offspring of radar operators, and controls finds a higher count of clustered de novo mutations (cDNMs) in children of irradiated parents (average 2.65 per child in the Chernobyl group, 1.48 in the radar group, 0.88 in controls), with higher parental radiation dose associated with more cDNMs. Most cDNMs occur in non-coding DNA, suggesting minimal disease risk, and the overall risk of disease in offspring remains small. The study notes limitations, including historical exposure estimates and potential participation bias, and emphasizes a transgenerational effect of prolonged low-dose ionizing radiation.