Understanding Tissue-Resident Macrophages and Their Role in Disease.
Macrophages are a diverse group of immune cells that play crucial roles in tissue homeostasis, development, and immunity. Recent studies have shown that tissue-resident macrophages originate from embryonic precursors and self-maintain locally throughout adult life with minimal contribution from circulating monocytes. Macrophages also have important functions in tissue growth and repair, as well as in regulating salt-dependent volume and blood pressure. They sense their environment through various receptors and respond to stimuli such as hypoxia and mechanical force.