Promising Treatment Route Discovered for Alzheimer's Disease
Researchers from the Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR) in Bengaluru have discovered that plant-based polyphenols, such as tannic acid found in trees like Chestnut and Oak, could be a cost-effective strategy for combating Alzheimer's disease (AD). The study found that these polyphenols have the potential to ameliorate ferroptosis, a form of programmed cell death associated with AD, by activating and enhancing the GPX4 pathway. The findings offer new avenues for targeting novel pathways in the development of therapeutics for AD and may inspire the exploration of natural compounds for enhanced efficacy against neurodegenerative diseases.