Managing Fluctuating MS Symptoms on Ocrevus: Debunking the Myth of 'Wearing Off'
Fluctuations in the severity of multiple sclerosis (MS) symptoms experienced by patients on Ocrevus (ocrelizumab) are likely due to the natural variability of MS symptoms rather than any direct biological effect of the medication, according to a study. Patients commonly report a 'wearing off' effect between infusions, but the study suggests that these experiences are attributed to natural fluctuations in MS symptoms rather than the timing of Ocrevus infusions. The study casts doubt on the existence of 'wearing off' as a consistent physiological phenomenon and emphasizes the need for further research to understand the fluctuations in symptom severity in MS patients.