All articles tagged with #sirna
Aerska, a Dublin/London biotech, raised $39 million in a second financing round to advance brain-shuttle delivery of siRNA that silences disease-causing brain genes, leveraging an iron-molecule–like carrier to cross the blood-brain barrier.
The article discusses how buffer optimization, specifically using mildly acidic, antioxidant-containing buffers like histidine, can significantly improve the room temperature stability of siRNA-lipid nanoparticles by mitigating lipid oxidation and RNA-lipid adduct formation, thereby extending shelf life and maintaining efficacy.
Tessera Therapeutics, a biotech startup developing gene editing tools, has revealed preliminary data from five preclinical programs using its "gene writers" to treat genetic diseases. Meanwhile, Comanche Biopharma, a new siRNA biotech, is nearing clinical trials for a one-time therapy to treat preeclampsia. The Supreme Court has ruled in favor of Sanofi and Regeneron in a patent battle with Amgen, and an FDA panel has backed Pfizer's RSV vaccine. Catalent has announced drastic measures to right its business, and Moderna has presented early data on its mRNA treatment for propionic acidemia.