Buffer Optimization Enhances siRNA-Lipid Nanoparticle Stability
Originally Published 3 months ago — by Nature
The article discusses how buffer optimization, specifically using mildly acidic, antioxidant-containing buffers like histidine, can significantly improve the room temperature stability of siRNA-lipid nanoparticles by mitigating lipid oxidation and RNA-lipid adduct formation, thereby extending shelf life and maintaining efficacy.