"Nanopore Technology Revolutionizes Protein Variant Detection"
Scientists at the University of Oxford have made a breakthrough in detecting modifications on protein structures using nanopore technology. The method allows for the identification of structural variations at the single-molecule level, even within long protein chains. By capturing and unfolding proteins using nanopores, the researchers were able to measure changes in electrical current to identify different post-translational modifications. This technique could enable the rapid building of protein inventories in single cells and tissues, potentially revolutionizing point-of-care diagnostics and personalized medicine.