"Unraveling the Link: Protein Synthesis and Cognitive Disorders"
Researchers at RIKEN have discovered a link between overactive quality control in protein synthesis and neurodevelopmental disorders, which can inhibit neural growth and communication, leading to cognitive dysfunction. By studying mice lacking a key gene in ribosome-associated quality control, the team found that the overexpression of a signaling molecule called TTC3 curbs the extension of neurites, reducing communication between neurons and causing cognitive dysfunction. This finding could pave the way for new therapeutic strategies to target TTC3 or other signaling factors to treat cognitive disorders.