Unveiling the Role of a Novel Hormone in Tumour-Induced Kidney Dysfunction
Researchers have discovered a novel antidiuretic hormone that regulates tumor-induced renal dysfunction. Using Drosophila as a model, the study found that tumors release a hormone called Ion Transport Peptide (ITP), which inhibits fluid secretion in the Malpighian tubules, leading to impaired kidney function. The researchers also identified the receptor for ITP and demonstrated its role in regulating water homeostasis. This study provides insights into the mechanisms underlying tumor-induced renal dysfunction and may lead to the development of new therapeutic strategies.