"Identification of Crucial Player in Pancreatic Cancer Metastasis"
Researchers at the University of California, Davis have identified a protein, Engrailed-1 (EN1), that is linked to the progression and metastasis of pancreatic cancer. The abnormal expression of EN1 promotes pancreatic cancer progression and metastasis in vitro and in mouse models, and elevated EN1 levels are associated with severe, metastatic pancreatic cancer in human patients. The findings suggest that EN1 could be a potential target for pancreatic cancer therapies, and the researchers are working on ways to translate their findings into clinical applications. This discovery sheds light on the molecular mechanisms driving metastasis in pancreatic cancer and could lead to the development of new therapeutic strategies for this challenging disease.