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Protein Language Models

All articles tagged with #protein language models

science-and-technology2 years ago

Advancing Protein Structure Analysis with AI and Geometric Deep Learning

Researchers have developed a novel approach to analyze protein structures by integrating pre-trained protein language models into geometric deep learning networks. By bridging the gap between 1D sequence understanding and 3D structure comprehension, the researchers harnessed the insights from protein language models to enhance the capabilities of geometric neural networks. This fusion allows for a comprehensive analysis of protein structures, promising to illuminate new realms of understanding in molecular biology.

science-and-technology2 years ago

"Revolutionizing Antibody Evolution with Protein Language Models"

Researchers have used protein language models to guide the directed evolution of human antibodies with unprecedented efficiency. The language models were used to identify plausible amino acid substitutions that were experimentally screened for improved fitness. The researchers evolved seven human immunoglobulin G (IgG) antibodies that bind to antigens from coronavirus, ebolavirus, and influenza A virus. The affinity of all antibodies was improved after measuring only 20 or fewer new variants of each antibody across just two rounds of evolution.