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Peptide Synthesis

All articles tagged with #peptide synthesis

science20 days ago•35 min saved

Water-Based Peptide Synthesis Could Slash GLP-1 Drug Manufacturing Waste

A Nature Sustainability paper reports that producing GLP-1 weight‑loss drugs (e.g., Ozempic) with traditional solid‑phase peptide synthesis releases large amounts of toxic solvents and plastic byproducts. Melbourne researchers have developed a water‑based peptide synthesis approach that could dramatically reduce waste and make manufacturing more sustainable, though it remains to be scaled commercially for thousands of peptide drugs.

via Yahoo|

#environmental-impact #glp-1 #peptide-synthesis

science-and-technology2 years ago•2 min saved

Harnessing Ribosomes: Unlocking the Potential of Chemical Libraries

A research team at the University of California, Irvine has developed a new method for creating large collections of chemical compounds used in drug discovery by utilizing ribosomes, the molecules responsible for protein synthesis. This innovative technique replaces the labor-intensive process of manually synthesizing and screening chemical libraries, allowing for the rapid discovery of new drugs. The team successfully generated gel beads containing ribosomes, RNA polymerase, and DNA cores that encode specific peptide molecules. This approach enables the synthesis and screening of vast libraries in parallel, advancing pharmaceutical discoveries and potentially benefiting other fields such as enzyme engineering and material development.

via Phys.org|

#chemical-libraries #drug-discovery #peptide-synthesis