Tag

Optogenetic Stimulation

All articles tagged with #optogenetic stimulation

neuroscience2 years ago

"Unraveling the Role of Dynamic Behaviour Restructuring in Dopamine-Dependent Credit Assignment"

Researchers have discovered that dopamine release plays a crucial role in reinforcing reward-producing actions. Using a self-stimulation paradigm, they found that dopamine self-stimulation dynamically reshapes the entire behavioral repertoire. Initial stimulations not only reinforced the target action but also similar actions and those occurring shortly before stimulation. Through repeated pairings, the behavioral repertoire gradually refined to focus on the target action. The study also revealed temporal dependencies in the refinement of action sequences. This retrospective reinforcement mechanism allows for the assignment of credit to specific actions and action sequences that lead to dopamine release.

science-and-technology2 years ago

Exploring the intricate link between the brain and gut.

MIT researchers have developed an electronic interface using specialized fibers embedded with sensors and light sources for optogenetic stimulation, allowing them to manipulate neural circuits connecting the brain and gut in mice. The technology has provided new insights into the complex relationship between these two vital organs, which has long been recognized but poorly understood. The fibers, as thin as human hair, can be inserted into the gut and other organs of interest, and are embedded with electrodes, temperature sensors, light-emitting devices, and microfluidic channels for drug delivery.