Genome Topography Reveals Surprising Link to Cancer Mutations
Researchers from the University of California San Diego have discovered a connection between the topography of the human genome and the presence of mutations in human cancer. Certain regions of the genome, with unique features, act as hotspots for the accumulation of mutations. The study highlights the potential influence of the human genome's 3D structure in the development of various forms of cancer. The researchers found that mutations linked to alcohol consumption tend to accumulate in regions of the genome that are copied early during cell division, contrary to expectations. Additionally, mutational signatures tied to antiviral activity accumulate in both early- and late-replicated regions of the genome. The findings provide valuable insights for understanding the role of topographical features in cancer development, evolution, and treatment.