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Mavenclad

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Updates on EBV vaccine trial, DMT costs, and Mavenclad in MS news.
multiple-sclerosis2 years ago

Updates on EBV vaccine trial, DMT costs, and Mavenclad in MS news.

EBViously plans to bring its candidate vaccine against the Epstein-Barr virus into clinical trials starting in 2024, which could reduce the incidence of MS. A study found that the costs of infusible DMTs, Ocrevus, Tysabri, and Lemtrada, accounted for more than three-quarters of the total costs, and controlling price markups for medications could help limit healthcare costs for patients. A real-world data study says the benefits of Mavenclad were sustained for up to 15 years after its last treatment course in people with relapsing MS. The FDA has put a partial hold on trials of evobrutinib in MS after two patients in Phase 3 clinical trials were found to have elevations in their liver enzymes.

Long-term benefits of Mavenclad for MS patients.
health2 years ago

Long-term benefits of Mavenclad for MS patients.

Real-world data from the CLASSIC-MS study showed that the benefits of Mavenclad (cladribine) were sustained for up to 15 years after its last treatment course in people with relapsing multiple sclerosis (MS). More than half of those who received the oral therapy in the clinical trials that supported its approval no longer needed further disease-modifying therapies (DMTs) and twice as many continued relapse-free over a median of 10.9 years compared with those never given it. Mavenclad is a short-course oral DMT approved for relapsing forms of MS, including relapsing-remitting MS (RRMS) and active secondary progressive MS (SPMS).