Tag

Homologous Recombination

All articles tagged with #homologous recombination

science5 hours ago•13 min saved

RAD51 Paralogs Unite to Scaffold DNA Repair Filaments

Researchers show that all five RAD51 paralogs can assemble into two distinct, ATP-dependent assemblies: a BCDX2-CX3 loader that templates RAD51 filament formation on ssDNA, and a RAD51B-independent DX2-CX3 anchor that caps and stabilizes the filament; together, these modular assemblies define loader vs. anchor roles in homologous recombination and illuminate disease-causing mutations.

via Nature|

#bcdx2-cx3 #dna-repair #dx2-cx3

science2 years ago•1 min saved

"Uncovering the Crucial Stages of a DNA Repair Breakthrough"

Scientists are studying the process of DNA repair, particularly homologous recombination (HR), which involves the RecA protein binding to a single-stranded end of broken DNA and using an intact DNA template to repair double-strand breaks, caused by various sources of damage, such as UV rays or errors during replication, that can lead to cell death or mutations like cancer.

via Interesting Engineering|

#dna-repair #double-strand-break #genetic-mutations