All articles tagged with #hiv reservoir
Researchers have developed a new mRNA delivery method using specialized lipid nanoparticles to make hidden HIV in white blood cells visible, potentially paving the way for a cure, though further research and trials are needed.
Scientists from Merck have discovered a subset of non-nucleoside reverse transcriptase inhibitor (NNRTI) drugs that not only inhibit HIV's ability to replicate but also cause the virus to kill off infected cells. These drugs, called Targeted Activators of Cell Kill (TACK), work by prematurely synthesizing HIV's protease enzyme, which then snips out cellular proteins that form a self-destruct bomb, destroying the infected cell. The TACK drugs offer a potential cure therapy that specifically targets HIV-infected cells, without relying on host immune responses. The lead candidate, Pyr01, has shown promising results in lab experiments, demonstrating strong antiviral activity and the ability to kill HIV-infected cells. Further research is needed to determine the safety and effectiveness of TACK drugs in clinical settings.