Understanding Immune Response to Heterologous Boosting and Omicron Infections
A study analyzed the immune response of healthcare workers who received two initial doses of the CoronaVac vaccine followed by 2 or 3 heterologous booster shots with either mRNA or DNA vaccines. The results showed that both DNA and mRNA booster vaccines increased levels of neutralizing antibodies and IFN-γ production, but had little effect on memory T cells. These findings support the use of booster vaccinations to maximize the effectiveness of immunity, especially for high-risk individuals.