Sleep deprivation triggers brain–gut signals that damage gut stem cells
New research in Cell Stem Cell shows sleep deprivation in mice activates a brain-to-gut signaling cascade via the vagus nerve, triggering a surge of serotonin in the gut that damages intestinal stem cells and impairs the gut’s regenerative capacity. The study links insomnia to gut dysfunction and suggests acetylcholine from the vagus nerve drives serotonin release, highlighting potential therapeutic targets to protect gut health in sleep-disordered individuals.
