Neuronal Activity Key to Astrocyte Shape: Study
Neuronal activity is necessary and sufficient for astrocytes to develop their bushy shape, which is fundamental for brain function. These findings suggest that astrocyte development and function involve a complex pattern of events and proteins triggered by the activity of neurons, offering new insights into the mechanisms of brain development and the potential causes of neurodevelopmental disorders. Astrocytes play diverse roles that are vital for proper brain function, including supporting the activity of neurons, participating in the formation and function of synapses, releasing neurotransmitters, and making the blood-brain barrier.