Study Links LRRK2 Variant to Reduced Tremor Progression
A study from China reveals that Parkinson's patients with the G2385R mutation in the LRRK2 gene experience slower tremor progression and less daytime sleepiness compared to those with idiopathic Parkinson's. The research, involving over 2,000 patients, also found that other LRRK2 mutations, R1628P and A419V, did not significantly affect symptoms compared to idiopathic cases. These findings highlight the need for further longitudinal studies to understand the clinical implications of LRRK2 mutations in Parkinson's disease.