A new drug from Cytokinetics, aficamten, showed improved exercise capacity over the common beta blocker metoprolol in a Phase 3 study for patients with hypertrophic cardiomyopathy, potentially accelerating its FDA approval and broader use.
Pliant Therapeutics has reported positive early-stage results from an exploratory study, indicating that patients with chronic liver disease who received its drug, bexotegrast, showed improved liver function compared to those who received a placebo. The study showed reduced levels of liver scarring biomarkers in patients who received the drug.
The New York State Psychiatric Institute has suspended all of its human research trials following the suicide of a participant in a Parkinson's drug study. The US Department of Health and Human Services is investigating whether safety protocols were violated. The study, led by Dr. Bret R. Rutherford, was testing the use of levodopa as a treatment for depression in older individuals. The institute had nearly 500 studies underway with budgets totaling $86 million before the suspension. Rutherford resigned from his position and three medical journals have retracted studies from his laboratory due to methodological errors.