"Trans-vaccenic acid enhances CD8+ T cells for improved anti-tumour immunity"
A study has found that trans-vaccenic acid (TVA), a dietary nutrient found in certain foods, enhances the function of CD8+ T cells and promotes anti-tumour immunity. TVA activates the GPR43 receptor and increases cAMP levels, leading to the activation of the CREB pathway. This results in enhanced production of cytokines, increased proliferation, and reduced exhaustion of CD8+ T cells. The findings suggest that TVA could be used as a dietary supplement to boost immune responses against cancer.