"Groundbreaking Study Identifies Promising Biomarker for Major Depressive Disorder"
Researchers from Korea have identified a neuroimaging-based biomarker, known as the local gyrification index (LGI), for major depressive disorder (MDD). The study found that patients with MDD had significantly lower LGI values in multiple cortical regions compared to healthy individuals, indicating hypogyrification or decreased cortical folding. The findings suggest that abnormal cortical folding patterns may be associated with the dysfunction of neural circuits involved in emotional regulation, contributing to the pathophysiology of MDD. The study's results provide a deeper understanding of MDD and pave the way for future research on genetic factors and targeted medical treatments.