'1938': A Promising Compound for Nerve Regeneration and Heart Protection
Researchers from UCL, MRC LMB, and AstraZeneca have discovered a new compound, named ‘1938’, that can promote nerve regeneration after injury and protect cardiac tissue from significant damage, as seen in heart attacks. The compound stimulates the PI3K signaling pathway, promoting cell growth. 1938 is one of just a few compounds in development that can promote nerve regeneration, for which there are currently no approved medicines. The group is now working to develop new therapies for peripheral nerve damage and exploring whether PI3K activators could be used to help treat damage in the central nervous system.