All articles tagged with #chronotherapy
A study suggests that administering immune checkpoint inhibitors earlier in the day, before 3 p.m., significantly improves survival outcomes for patients with extensive-stage small cell lung cancer, highlighting the potential of chronotherapy to optimize cancer treatment by aligning it with the body's circadian rhythms.
Research from Washington University in St. Louis reveals that glioblastoma, a type of aggressive brain cancer, synchronizes its growth with the host's circadian rhythms, particularly leveraging daily hormone cycles. Blocking these signals in mice slowed tumor progression, and the timing of treatments like dexamethasone (DEX) was found to be crucial, with evening doses suppressing tumor growth. This suggests that chronotherapy, or timing treatments to the body's internal clock, could be a promising personalized approach to managing glioblastoma.
Cancer chronotherapy, which aims to optimize cancer treatment to the circadian rhythm, is still in its early days. However, research suggests that cancer activity is influenced by the circadian rhythm, and that the timing of cancer treatment may affect its safety and effectiveness. Studies of timed chemotherapy and immunotherapy have shown success in reducing side effects and increasing survival times for certain cancers. However, more research is needed to fully understand the nuances of how different cancer drugs may vary in effectiveness depending on the time of day they are given to patients.
The circadian rhythm plays a crucial role in cancer development, diagnosis, and treatment, according to a review paper published in the journal Trends in Cell Biology. The authors argue that leveraging the timing of cancer cells' circadian rhythms could improve diagnostic accuracy and treatment success. Chronotherapy, the practice of delivering medication and immune therapies at specific times of day, could be a valuable alternative treatment option in the fight against cancer. Clinical studies have shown that chronotherapy can reduce the severity of side effects experienced by patients and can also impact treatment effectiveness.