"Uncovering the Secrets of Chromosome Immortality"
Recent research challenges the long-standing understanding of the end-replication problem in DNA, revealing two distinct issues rather than one. Telomerase and the CST–Polα-primase complex are both essential for chromosome protection, addressing the leading and lagging-strand problems in DNA replication. This discovery may lead to a revision in the science of telomeres and potential impacts on genetic disorders, offering new insights into maintaining chromosome immortality.