Tag

Cellular Signaling

All articles tagged with #cellular signaling

Visualizing G Protein-Coupled Receptor Communication for Drug Discovery

Originally Published 2 years ago — by Phys.org

Researchers at the Indian Institute of Technology Kanpur have discovered a novel mechanism that regulates G protein-coupled receptors (GPCRs), a class of drug targets involved in regulating heart function, blood pressure, mental disorders, and behavior. The researchers used cryogenic-electron microscopy to visualize the cross-talk of GPCRs and arrestins in great detail, providing a complete understanding of GPCR-arrestin interaction. This discovery has important implications for understanding cellular signaling in the human body and could facilitate novel drug discovery for several human disease conditions.

health science-and-technology arrestins cellular-signaling cryogenic-electron-microscopy drug-discovery g-protein-coupled-receptors science-and-technology

Discovery of new phosphate-storing organelle in fruit fly gut.

Originally Published 2 years ago — by Phys.org

Scientists at Harvard Medical School studying phosphate transport in fruit fly intestines have discovered a new organelle, named PXo bodies, that stores phosphate. The organelle was found to be storing phosphate in a multilamellar membrane, and when the gene PXo was downregulated or missing, the PXo bodies degraded, releasing the backup storage of phosphate into the cell. The discovery could lead to further research into the organelle's functions and interactions in other life forms.

science science cellular-signaling fruit-flies harvard-medical-school organelles phosphate-transport science