"Novel Dual CRISPR Gene Editing Strategy Eliminates HIV Infection in Animals and Mice"
Researchers at the Lewis Katz School of Medicine at Temple University and the University of Nebraska Medical Center have used CRISPR-based technology to inactivate CCR5 and excise HIV-1 DNA fragments from infected cells in humanized mice that were also treated using long-acting antiretroviral drugs. The work is the first to combine a dual gene editing strategy with antiretroviral drugs to cure animals of HIV-1. The new dual CRISPR gene-editing strategy holds exceptional promise for treating HIV in humans, the researchers believe.