Identifying Candidate Genes for Insulin Action and Dysglycemia.
A genome-wide association study (GWAS) and functional characterization have identified candidate genes for insulin-stimulated glucose uptake, a key factor in the development of insulin resistance and type 2 diabetes. The study analyzed data from over 50,000 individuals and identified 42 genetic loci associated with glucose uptake. The study also identified several candidate genes, including TBC1D4, which has previously been linked to insulin resistance. The GWAS summary statistics and data from the Fenland cohort are available for researchers, and all data used in genetic risk score association analyses are available from the UK Biobank.