The Link Between Calcium Uptake and Chronic Inflammation
Impaired mitochondrial uptake of calcium ions in macrophages, a type of immune cell, has been found to contribute to age-related changes in inflammatory responses, according to a study published in Nature Aging. The researchers discovered that reduced calcium uptake in macrophages leads to an amplified inflammatory response, both at baseline and when stimulated. This finding sheds light on the mechanisms behind inflammaging, the gradual increase in inflammation with age, and suggests that targeting the mitochondrial calcium uptake pathway could potentially modulate age-related changes in inflammation.