Liberating GPCRs: A New Approach.
Nobel laureate Bob Lefkowitz discusses the future of drug discovery targeting G-protein-coupled receptors (GPCRs), which are involved in many physiological processes and are the target of about one-third of all drugs. Lefkowitz emphasizes the importance of understanding the structure and function of GPCRs to develop more effective drugs and highlights the potential of new technologies such as cryo-electron microscopy and gene editing to advance GPCR research.