Revolutionary Technique Unveiled: Spotting Brain Capillary Blood Flow Issues Made Easier
Researchers have developed a new method using Bessel beam two-photon microscopy to detect stalling events in brain capillaries, which can indicate acute neurological issues and are linked to chronic conditions like Alzheimer's and Parkinson's diseases. The technique allows for faster imaging with better temporal resolution compared to current methods, and a semi-automated analysis approach makes the identification of stalling events easier. The researchers also found that visualizing the intensity correlation in the images was more reliable for detecting stalling than observing raw images. This method has the potential to aid in the investigation, diagnosis, and treatment of brain diseases.