Improving rare variant association analyses with adjusted polygenic scores.
Adjusting for common variant polygenic scores can improve the yield in rare variant association analyses, according to a study using data from the UK Biobank. The researchers found that incorporating polygenic scores into the analysis increased the power to detect rare variant associations, particularly for traits with a strong polygenic component. The study highlights the importance of considering both common and rare genetic variation in association analyses and provides a resource for researchers to access the data and code used in the study.