Decoding Alzheimer's Mutation: Unique Brain Plaques Unveiled
Researchers have decoded the structure of amyloid beta fibrils linked to the Arctic mutation, a rare inherited form of Alzheimer's disease, using cryo-electron microscopy and NMR. This mutation leads to the formation of unique cottonwool plaques, which are significantly larger than typical Alzheimer's plaques. Understanding these structures could guide the development of targeted therapies, particularly antibody-based treatments, for specific Alzheimer's subtypes.