Tag

Aplp1

All articles tagged with #aplp1

health6 months ago

Cancer Drug Shows Promise in Slowing Parkinson's Disease

Scientists have discovered that an existing cancer immunotherapy drug, nivolumab–relatlimab, shows promise in slowing Parkinson’s disease progression by blocking the spread of toxic protein clumps in the brain, through disrupting a partnership between two proteins, LAG-3 and Aplp1, involved in the disease mechanism. This repurposing could lead to new treatments that slow or halt disease progression.

health7 months ago

Potential FDA-Approved Treatment for Parkinson's Discovered

Researchers have identified how a surface protein called Aplp1 interacts with Lag3 to facilitate the spread of toxic alpha-synuclein in Parkinson's disease. An existing FDA-approved cancer drug targeting Lag3 has been shown to block this process in mice, suggesting a potential treatment for Parkinson's may already exist. Further testing on mouse models is planned to explore this promising approach.