All articles tagged with #antigens
MIT researchers have identified potential new targets for a tuberculosis vaccine by screening bacterial proteins and testing immune responses, aiming to develop a more effective vaccine than the current BCG, with promising results from mRNA vaccine experiments in human cells.
Despite the increase in the number of vaccine doses given to children over the years, modern vaccines expose children to far fewer antigens and similar or lower levels of aluminum than vaccines from decades ago, thanks to advances in vaccine engineering. This reduction in immune burden, combined with the significant public health benefits of vaccination, highlights that concerns about 'too many, too soon' are largely based on misconceptions rather than scientific evidence.
Scientists in Germany have developed a new method to display epitopes in mammal cells for immunization studies, potentially revolutionizing vaccine development. By fusing antigen proteins into a tetraspanin-derived anchor membrane-bound protein, the researchers created fusion proteins that are displayed predominantly on the surface of human cells. This new display technology allows for the production of antibodies against specific viral proteins without the need for antigen purification, speeding up the immunization process. The researchers believe this technique could be particularly valuable in developing vaccines against diseases like HIV-1.