Blocking PTP1B boosts brain cleanup and memory in Alzheimer’s mice
In a mouse model of Alzheimer’s disease, researchers found that inhibiting the brain enzyme PTP1B enhances microglial clearance of amyloid-beta by boosting SYK signaling, improving learning and memory. Because PTP1B is already a target for metabolic disorders, this approach could complement existing amyloid-clearing therapies and pave the way for combination treatments to slow disease progression.