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Aav

All articles tagged with #aav

"Revolutionizing Protein Engineering with Computational Techniques and AI Integration"

Originally Published 1 year ago — by MIT News

MIT researchers have developed a computational approach to predict mutations that will lead to improved proteins, making it easier to engineer proteins with useful functions. Using a convolutional neural network trained on experimental data, the researchers created fitness landscapes to predict optimized versions of green fluorescent protein (GFP) and a protein from adeno-associated virus (AAV). The approach has the potential to accelerate the process of optimizing proteins for research and medical applications, and could be applied to other protein engineering problems.

health science-and-technology aav computational-technique gfp mit protein-engineering science-and-technology

In Vivo Prime Editing Achieved with Dual AAVs.

Originally Published 2 years ago — by Genetic Engineering & Biotechnology News

Researchers have demonstrated high-efficiency, therapeutically-relevant prime editing in vivo in mice with a dual-AAV system, demonstrating prime editing in the mouse brain and liver by installing putative protective mutations in vivo for Alzheimer’s disease in astrocytes and for coronary artery disease in hepatocytes, respectively. The study opens the door to creating a wide variety of prime editing therapies, which will allow a much larger number of diseases and groups of patients to be addressed than has been before with editing technologies.

health science-and-technology aav gene-editing in-vivo prime-editing science-and-technology therapeutics