Link Between Rare Embryo Mutations and Schizophrenia Risk Sparks Treatment Concerns

Rare genetic mutations that occur during the early stages of embryo development may increase the risk of developing schizophrenia later in life, according to researchers. These non-inherited mutations, known as somatic mutations, were found in genes NRXN1 and ABCB11. NRXN1 mutations were present in blood cells of individuals with schizophrenia and are believed to affect the brain's connections between nerve cells. ABCB11 mutations were found in dopamine-producing neurons and may impact the effectiveness of schizophrenia drugs. The findings could lead to new insights and potential treatments for the condition.