The Interplay of RNA and DNA Methylation in Stem Cell Fate and Transposable Element Regulation

A study has revealed the crosstalk between RNA m6A and DNA methylation in regulating transposable element chromatin activation and cell fate in human pluripotent stem cells. The researchers found that RNA m6A modification influences DNA methylation patterns, leading to changes in chromatin accessibility and gene expression. This interplay between RNA m6A and DNA methylation provides insights into the regulation of transposable elements and their impact on cell fate determination.