Maintaining Accuracy in Protein Synthesis: Insights from mRNA Reading Frame Maintenance

Researchers have made atomic coordinates and cryo-EM maps available for complexes involved in mRNA reading frame maintenance during eukaryotic ribosome translocation. The study sheds light on the mechanisms of translation elongation and the role of GTP hydrolysis in translocation, providing insights into the fidelity of mRNA translation and potential targets for selective inhibition of protein synthesis.