The Effects of High Altitude on Metabolism Unveiled by New Research

Researchers at the Gladstone Institutes have discovered how chronically low oxygen levels, such as those experienced at high altitudes, alter the way mice burn sugars and fats. The findings offer insights into the metabolic differences of individuals residing at high altitudes and pave the way for the development of novel treatments for metabolic disease. The study showed that different organs reshuffle their fuel sources and their energy-producing pathways in various ways when exposed to chronically low levels of oxygen. The lasting effects of long-term hypoxia seen in the mice, lower body weight and glucose levels, are both associated with a lower risk of diseases in humans, including cardiovascular disease.