Unveiling the Unconventional TRPV3 Channel: A Dilated Pore Defying Dogma

Researchers have discovered a pentameric TRPV3 channel with a dilated pore using cryo-electron microscopy (cryo-EM) and structural modeling. The cryo-EM maps of the TRPV3 tetramer and pentamer have been deposited in the Electron Microscopy Data Bank, providing valuable insights into the structure and function of TRPV3 channels. This finding contributes to our understanding of ion channels and their potential as drug targets.