Do antidepressants define your true self? A measured look at staying on or stopping

A Vox Future Perfect column explores whether long‑term antidepressants change who we are, noting that the science shows antidepressants help some people more than placebo but the exact mechanisms remain unclear. It introduces a framework of ‘medication career’ and ‘moral career’ to frame decisions alongside a clinician, argues there isn’t a single fixed ‘true self,’ and emphasizes weighing benefits against costs. If stopping is pursued, the piece urges gradual tapering with professional guidance and awareness of withdrawal and dependence versus addiction.