Unveiling Tissue-Specific Disease Contributions through Co-Regulation Modeling

A review of scientific literature on tissue-specific regulation and its role in disease etiology highlights various methods and approaches used to identify trait-relevant tissues and cell types. These include leveraging gene co-expression patterns, integrating epigenomic data, and conducting transcriptome-wide association studies. The research emphasizes the importance of understanding tissue-specific contributions to complex traits and diseases for improved diagnosis and treatment strategies.